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Patients should be aware of symptoms suggesting gallbladder disease, including right upper quadrant abdominal pain, particularly after fatty meals, and should seek medical evaluation if such symptoms occur
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Amino acid substitutions : Specific amino acids within the peptide backbone are reported to have been substituted or modified to improve resistance to enzymatic degradation, including by dipeptidyl peptidase-4 (DPP-4), thereby improving metabolic stability
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