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It is worth noting that GLP-1 receptor agonists show neutral effects on heart failure hospitalisation, unlike SGLT2 inhibitors which demonstrate benefit in this area

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The residual pocket is lined by Asn-300 ECL2 , Asn-302 ECL2 , Tyr-305 5.35 , Trp-306 5.36 , Arg-310 5.40 , Phe-367 6.56 , Ala-368 6.57 , Phe-369 6.58 , Met 371 ECL2 , Asp-372 ECL2 , Arg-380 7.34 and Lys-383 7.37 , with the base being formed by two free main chain carboxy groups at the C-terminal end of TM6