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While these findings do not establish additive or synergistic effects, they raise a biologically plausible hypothesis: that combined metabolic support—improving glucose handling while simultaneously supplying alternative fuels—may outperform either strategy alone

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Women should not only rely on oral contraception in such a situation but either add a barrier contraception method for 4 weeks after initiation until four 4 weeks after the last dose escalation of tirzepatide or switch to a completely nonoral contraceptive method (61)