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Key findings from published and presented studies include: In a phase 2 obesity trial, higher‑dose retatrutide produced average weight loss of around 22.8–24.2% over 48 weeks in people with obesity.​ In participants with type 2 diabetes, retatrutide achieved substantial weight loss and marked improvements in blood sugar and cardiometabolic markers, though average percentage weight loss was somewhat lower than in non‑diabetic obesity cohorts.​ Early studies also reported significant reductions in liver fat and visceral adipose tissue, with a high proportion of participants with fatty liver disease showing resolution of hepatic steatosis at higher doses.​ These results have led several reviews to describe retatrutide as a potential “game changer” in obesity pharmacotherapy, representing the first GLP‑1/GIP/glucagon triple agonist with robust human data.​ Popular coverage has highlighted phase 3 data suggesting average weight losses approaching 29% of body weight in some cohorts (roughly 71 pounds), which is about double typical results with semaglutide over comparable periods