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The IgG4 Fc was selected over other immunoglobulin subclasses because it exhibits minimal complement fixation and antibody-dependent cellular cytotoxicity (ADCC), properties that are undesirable in a chronically administered therapeutic protein
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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Hartwig F.P., Davey Smith G., Bowden J
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