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According to FDA labeling for Wegovy (semaglutide 2.4 mg), patients should be evaluated after 12 weeks at the maintenance dose, and discontinuation considered if less than 5% weight loss has been achieved

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During phase 1 trials in NASH patients, efocipegtrutide showed a half-life of around 5.9 days, and was capable of reducing body weight by 5.1% when administered weekly at 0.08mg/kg, after 12 weeks [36]