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In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: –15.0% for 5 mg, –19.5% for 10 mg, –20.9% for 15 mg, compared to –3.1% for placebo [18]
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