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Bu noktada altta yatan mekanizmalardan biridegastrointestinalsistem(mide-duodenum-ince barsak-pankreas)den salgılanan incretinlerdir(peptitlerdir).Bu peptitleroreksijenik(iştah arttırıcı) ve anoreksijenik(iştah kapatıcı) olarak iki grupta yer alır
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