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Previous studies have analyzed the remodeling effect of metformin on gut microbiota and its metabolites and revealed that glycoursodeoxycholic acid (GUDCA) and intestinal farnesoid X receptor (FXR) are new targets for treating metabolic diseases associated with obesity
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4 MERCS as a structural signaling platform to GLP-1 receptor Contemporary understanding of the GLP-1R has transitioned from a model of linear, diffuse signaling at the plasma membrane to a sophisticated architecture of spatiotemporally organized nanodomains known as signalosomes ( 2+ flux, lipid transport, and bioenergetic restoration
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