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For the newer-generation therapies there was increased risk of nausea compared with placebo: semaglutide relative risk (RR) 2.95 (95% CI 2.61–3.32), tirzepatide RR 2.90 (95% CI 2–4.19), and orforglipron RR 4.77 (95% CI 2.02–11.31)

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This peptide selectively blocks N-type calcium channels in the spinal cord, providing pain relief for severe chronic pain without the tolerance and addiction risks of opioids