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The antibody epitope of the ECD does not overlap with the peptide-binding site, consistent with the non-competitive nature of the antibody in the cAMP assay (Fig
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These neurobiological findings indicate central engagement of mesolimbic circuits relevant to addiction and support a potential role for GLP-1R agonists in modulating incentive salience and dopaminergic tone, even in the absence of overt clinical behavioral differences [79]
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