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This finding led us to investigate whether improving CFTR function using drugs prescribed for cystic fibrosis patients, such as the CFTR potentiator VX-770 (Ivacaftor) 92 and the second-generation CFTR corrector VX-445 (Elexacaftor) 93,94,95 , often used in combination with the first-generation CFTR corrector Tezacaftor, could produce similar effects