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27 Primarily, GLP‐1 (7–36) lowers blood glucose levels by promoting insulin secretion and decreasing glucagon release in a glucose‐dependent manner by the mTOR‐dependent HIF‐1α activation pathway in pancreatic cells (Figure 1)
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Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms