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Dopamine plays a prominent role in the immediate reinforcing/rewarding effects of drugs—‘the dopamine theory’, and dysregulation of the dopamine system is thought to contribute to the addicted state as a predisposing factor and/or a consequence of chronic substance use (Volkow, Michaelides, et al., 2019)

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When to Seek Immediate Medical Attention Contact your healthcare provider or seek emergency care if you experience: Severe abdominal pain that does not go away Signs of an allergic reaction (rash, swelling, difficulty breathing) Symptoms of pancreatitis (severe abdominal pain, vomiting) Symptoms of severe dehydration (dizziness, confusion, rapid heartbeat) FDA Adverse Event Reporting To report medication side effects to the FDA, visit www.fda.gov/medwatch or call 1-800-FDA-1088