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Michaelโs Hospital and the University of Toronto told Global News that while โthe oral pill offers convenience, that may come at the expense of effectiveness.โ Novo Nordisk advises patients to speak with their doctor about potential side effects before starting RYBELSUS and positions the drug as part of a broader regimen that includes diet, exercise and standard cardiovascular and diabetes care.
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In trials, tirzepatide and retatrutide had slightly higher rates of GI effects than semaglutide due to the additional pathway activation
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