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A long-acting release form of exenatide (exenatide ER, Bydureon®) was approved by the FDA in 2012, becoming the first once-weekly injection of a GLP-1RA for adults with T2DM [ Table 2 ]

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And beyond the cost, there is the inconvenience of waiting for a replacement, the possibility of missing doses, and the disruption to a treatment plan that was finally working