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This is a big reason why experts compare GLP‑1s to other chronic‑disease medications like antihypertensives: once you remove the intervention, the underlying biology tends to reassert itself unless something else (like intensive lifestyle therapy) fills the gap

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One study examined gastric retention using 4-hour emptying scintigraphy 10 , which showed increased solid phase retention of 72% and 37% at 2 and 4 hours, respectively, in the semaglutide arm