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When to Avoid Semaglutide and Seek Personalized Guidance Semaglutide is generally not recommended if you have active ulcerative colitis, recent hospitalization for a flare, or a history of severe IBD complications such as toxic megacolon or perforation

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This decrease in circulating markers of the RAAS has not been consistently observed in human mechanistic studies, possibly due to differences in the study cohorts involved in these trials [68]