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When you eat a meal, GLP-1 is released into your bloodstream and does several things simultaneously: it signals to your brain that you're full, slows the rate at which your stomach empties food into the intestine, stimulates your pancreas to release insulin in proportion to blood sugar levels, and suppresses glucagon (a hormone that would otherwise raise blood sugar)

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The development of insulin resistance is associated with a variety of factors, including obesity, genetic background, and defects in insulin signaling pathways (Saisho, 2015)