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Mental Health Effects of GLP-1 Drugs | What Research Say
The agonist NLY01 exemplifies this mechanism by crossing the blood-brain barrier to directly target microglial GLP-1Rs, in addition to blocking dopaminergic neuron loss in Parkinson's models through preventing microglia activation and generation of neurotoxic reactive astrocytes [47] and potentially PI3K/AKT-mediated survival pathways [24] (Fig
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