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Some patients develop true dehydration, especially during: The first 4 weeks of treatment (when GI side effects are highest) Dose escalations from 0.25 mg up through 1.7 mg and 2.4 mg Episodes of vomiting or diarrhea Hot weather or heavy exercise Long travel days with limited fluid access Signs that thirst has crossed into dehydration: Dark yellow or amber urine
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It should be further noted that GLP-1R agonists decrease the intake of various drugs of abuse in rodents (for review see (70)) and that the use of multiple drugs is common (for review see (71))
