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When taken with semaglutide, which already slows digestion and can cause gastric irritation, the combination increases your risk of stomach upset, ulcers, and bleeding
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This distinction classifies patients into two dominant categories: a metabolic phenotype, characterized by comorbidities such as type 2 diabetes, hypertension, obstructive sleep apnea, and polycystic ovary syndrome), and a central/behavioral phenotype, dominated by behavioral and psychological factors such as increased cravings, emotional eating, smoking addiction, and depression
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
