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Similarly, in the presence of the GLP-1R antagonist Exendin(9โ39) (Ex9, 100 nM), Ex4 failed to relax cardiac pericytes (capillary diameters remained reduced by 16.2ยฑ2.6% of the initial diameter at n = 22 pericytes in 5 hearts, p = 5.1 ร 10 โ4 compared to Ex4 only, one-way ANOVA with ล รญdรกkโs test on final-minute values, Fig
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Tirzepatide has a dual-action mechanism, targeting multiple hormone pathways