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Conclusion While combination therapy with SGLT-2 inhibitors and GLP-1 receptor agonists holds promise for addressing residual cardiovascular risk in type 2 diabetes, its optimal use requires nuanced consideration of patient subpopulations, safety, and cost-effectiveness

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Lilly leads with retatrutide and orforglipron, while Novo has CagriSema, Amycretin, and oral semaglutide