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GLP-1 tự nhiên có thời gian bán hủy rất ngắn, chỉ khoảng 1-2 phút tùy loài, do hai nguyên nhân chính là GLP-1 bị phân hủy bởi enzyme dipeptidyl-peptidase 4 (DPP-4) và GLP-1 thải trừ nhanh qua thận
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Semaglutide has been shown to improve liver labs, modulate lipid metabolism, and lower hepatic inflammation, with effects that appear at least partly independent of weight loss
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