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doi: 10.1016/j.biopha.2020.110958 [DOI] [PubMed] [Google Scholar] 16.Qi X, Yun C, Sun L, et al
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Two formulations address different pharmacokinetic needs: Byetta (immediate-release) : 2.4-hour half-life, twice-daily injection 60 minutes before meals Bydureon (extended-release) : Exenatide encapsulated in PLGA microspheres for sustained release, enabling once-weekly dosing Liraglutide: Human GLP-1 Analog# Liraglutide is a 31-amino acid peptide with 97% homology to native human GLP-1