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Clinical trials such as the STEP programme (semaglutide) and SUSTAIN studies show that: Initial weeks : Modest weight loss primarily from reduced caloric intake Months 2–3 : More noticeable reduction becomes evident Months 3–6 : Continued steady weight loss as dose escalates Months 6–12 : Peak weight loss approaches, with most studies showing maximal effect by 12–18 months It is important to recognise that GLP-1 medications require dose titration —starting at a low dose and gradually increasing over several weeks according to the specific product's SmPC

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