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Among them, CHU-128 is a small molecule agonist from a series of compounds patented by Chugai (transferred to Eli Lilly in 2018)
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For example, sitagliptin is primarily eliminated unchanged through the urinary system, while Vildagliptin is metabolized in the kidneys in an inactive metabolites, with about a quarter of it being excreted unchanged in the urine
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