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Byetta is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

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Preliminary studies indicate that combining GLP-1RAs with opioids may lead to a decrease in the dose of opioids necessary, thereby decreasing the risk of opioid addiction and side effects [109]