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Clinicians are also cautious about prescribing these drugs to individuals with a history of eating disorders, where appetite suppression and weight loss may trigger relapse

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For instance, microglia adopt two distinct DAM phenotypes when responding to amyloid pathology and myelin damage in 5xFAD mice with dysfunctional myelin ( Cnp −/− 5xFAD mice), which may reflect the comorbid state of the aged brain