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41 Hexafluoroleucine containing peptide ( 7 ) has Glu 9 replaced with hexafluoroleucine and showed binding affinity and potency (IC 50 = 5.1 nM, EC 50 = 2.0 nM) comparable to GLP-1 (IC 50 = 1.9 nM, EC 50 = 1.0 nM)
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During the process, influx of glucose ensures sufficient ATP to sustain the stimulatory effect
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