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Subsequently, SIRT1 can deacetylate the nuclear factor ฮบB p65 subunit (NF-ฮบB p65) (82), thereby inhibiting the transcription of inflammatory genes such as NLR family pyrin domain containing 3 (NLRP3), interleukin-1ฮฒ (IL-1ฮฒ), interleukin-6 (IL-6) and upregulate the expression of anti-inflammatory molecules like interleukin-10 (IL-10) (80)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Liu T., Zhou L., Chen Y., Lin J., Zhu H
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