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Discovery and development of dipeptidyl peptidase-4 inhibitors - Wikipedia

In fasted states, the GLP-1 agonist Exendin-4 attenuates glucose-6-phosphatase and maintains glycogen synthase (GYS) activity but has no effect in PASK-deficient mice, whereas they already maintain an elevated level of expression of GYS [142]

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GLP-1-based therapeutics: simultaneously addressing glycemic control and body weight