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In the preclinical evaluation of twincretin in concussive head injury by Bader and colleagues (100), a direct comparison was made to liragultide treatment—a 247.6 μg/kg dose of liraglutide in mouse, which translates to a 1.8 mg dose in an 88.8 kg human, provided similar efficacy to a 5-fold lower dose of twincretin (50 μg/kg) to mitigate TBI-induced neuroinflammation, neuronal loss and behavioral impairments