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Interestingly, unpublished results for the orally available biased agonist TTP273 ( show a very effective reduction in HbA1c at 12 weeks that approaches that reported separately (Frias et al., 2020) for tirzepatide (1.7% versus 2.0%), a slightly less impressive effect on weight loss (3.8 kg versus 5.5 kg) and a markedly lower incidence of nausea