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The incretin mimetics, glucagon-like peptide-1 receptor agonists (eg, semaglutide, liraglutide) and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist (ie, tirzepatide), demonstrate the greatest weight loss benefits, with tirzepatide achieving reductions exceeding 20% in some patients

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Eligibility typically includes a BMI ≥35 kg/m² with weight-related comorbidities (with lower thresholds for some ethnic groups), and treatment is usually provided through specialist weight management services with specific duration limits