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Denial rate for weight-loss GLP-1s is higher at 35%, often due to BMI documentation gaps or missing behavioral intervention records

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The novel biguanide MC001 showed much stronger antitumor effect and relatively weaker proglycolytic activity compared with metformin as shown in vitro in colorectal cancer cells ( in vitro by modulating the AMPK-mTOR and androgen receptor signaling pathways ( In vivo , NT1014 reduced tumor weight by 61%, whereas metformin by only 32%