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GLP-1 agonists mimic the body’s natural GLP-1 hormone, helping regulate blood sugar, suppress appetite, and promote weight loss
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Mapping semaglutide in rodents gave a compatible picture: it did not cross the blood-brain barrier, reaching the brain through circumventricular organs and sites adjacent to the ventricles, with c-Fos activity appearing in ten areas including regions carrying no direct receptor contact (Gabery et al., JCI Insight , 2020)
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