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SGLT2i, by blocking glucose and with it sodium reabsorption in the proximal tubule, increases sodium delivery to the JGA and turns off the signal responsible for increased afferent arteriolar plasma flow, thereby decreasing the elevated intraglomerular
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The prior authorization must specify the exact dose (e.g., "semaglutide 1 mg subcutaneous weekly") and the duration of therapy (typically 90 days for the initial authorization, 365 days for renewals)
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