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Multiple mechanisms are involved in facilitating a tumor-specific drug accumulation, including receptor-mediated endocytosis through gp60 receptors and endothelial cells that enhanced permeability and retention (EPR) effects to tumor tissues and an albumin’s affinity for the SPARC (secreted protein acidic and rich in cysteine) [16, 68]

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4 The MHRA approved Wegovy for this cardiovascular indication in July 2024