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In the ATTAIN-1 phase 3, randomized trial, the use of orforglipron, an oral glucagon-like peptide-1 receptor agonist, led to significant mean body-weight reductions in patients with obesity, as compared with placebo. Full
there is a substantial inter-individual variability in treatment effects ( 2.1.1 Effects on lipid structure and on the liver The SURPASS-2, where TZP (with metformin) was compared to semaglutide (88), showed adjunctive effects, such as lowering the concentrations of LDL and triglycerides and elevating the concentration of HDL
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Dose:2.5 mg
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