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Clinical trials have indicated that GLP-1 RA–induced weight loss in older adults can result in measurable reductions in lean mass, with the proportion of lean tissue loss varying depending on the specific GLP-1 RA, dose, treatment duration, and concurrent lifestyle interventions (see Table 1)

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GLP-1 medications also have an appetite suppressing effect (anorexigenic effect), so pairing Ozempic and coffee or Zepbound and coffee and other GLP-1 medications and coffee could amplify this effect, thereby presenting a challenge to consuming a nutrient-dense diet