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While exendin-4 triggered a similar degree of mitochondrial network remodelling as above in Control RNAi-treated cells, SPHKAP knockdown resulted in disrupted mitochondrial morphology at vehicle conditions, which somewhat resembled that of exendin-4-stimulated Control RNAi-treated cells in terms of tubularity but had further visual abnormalities
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124 Whilst there have been suggestions of a potential association with intestinal obstruction, 125 a Danish health registry analysis of 4430 patients with IBD found no increased risk of bowel obstruction or ileus associated with GLP-1RA
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